Most of the time it’s natural, although embarrassing, but drooling in your sleep can also be a sign of some medical issue. If you have a condition that causes increased salivation then this could be the problem, considering it’s a little harder to control what your spit is doing in your mouth once you’re asleep. It could be a sign of sleep apnea or a blocked airway too though. Having trouble breathing could lead to sleeping with your mouth wide open to try to take in more air, and while your mouth is wide open it’s pretty easy for drooling to happen.